A restriction enzyme, restriction endonuclease, REase, ENase or restrictase is an enzyme that cleaves DNA into fragments at or near specific recognition sites within molecules known as restriction sites. [1] [2] [3] Restriction enzymes are one class of the broader endonuclease group of enzymes. Restriction enzymes are commonly classified into ... MmeI, a Type IIG REase with both methyltransferase (MTase) and REase activities in the same polypeptide, recognizes the target sequence TCCRAC using the target recognition domain (TRD) within its MTase component. This represented an excellent opportunity to engineer altered sequence specificity into the REase. Died. April 6, 1991. San Francisco, California, U.S. Known for. Class-action lawsuit against the St. Mary's Hospital in San Francisco. Eleanor Riese (1943–1991) was an American patient who sued a hospital for her right to refuse antipsychotic medication. 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